Description
NAD⁺ 500 peptide for sale
Nicotinamide adenine dinucleotide (NAD⁺) is a coenzyme found in all living cells and is essential for fundamental biological processes. It plays a critical role in energy metabolism, cellular repair, and signaling pathways.
- NAD⁺ exists in two forms:
- NAD⁺ (oxidized form) – accepts electrons.
- NADH (reduced form) – donates electrons.
The balance between NAD⁺ and NADH is vital for redox reactions, mitochondrial function, and overall cellular health.
NAD + for sale – Chemical Structure
- Composition: NAD⁺ is a dinucleotide composed of two nucleotides: one containing adenine and the other containing nicotinamide.
- Linkage: The two nucleotides are joined through their phosphate groups.
- Molecular Formula: C₂₁H₂₇N₇O₁₄P₂.
- This structure allows NAD⁺ to act as an electron carrier in metabolic reactions.
Biological Functions of NAD⁺ 500 peptides for sale
Energy Metabolism
NAD⁺ is central to glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation.
Acts as a coenzyme in redox reactions, shuttling electrons to produce ATP, the cell’s energy currency.
DNA Repair & Cell Maintenance
NAD⁺ serves as a substrate for PARPs (poly ADP-ribose polymerases), enzymes critical for DNA repair.
Epigenetic Regulation
NAD⁺ is required by sirtuins, a family of NAD⁺-dependent deacetylases that regulate gene expression, stress resistance, and aging pathways.
Cell Signaling
Functions in intracellular signaling as a precursor for molecules like cyclic ADP-ribose, which influences calcium signaling.
Decline of NAD⁺ with Age
Research shows that NAD⁺500 for sale levels naturally decline with age, contributing to:
Decreased mitochondrial efficiency
Impaired DNA repair
Increased oxidative stress
Age-related metabolic disorders
This decline is considered a hallmark of cellular aging.
NAD+ NAD decline with age
Boosting NAD⁺ Levels
Several strategies are under investigation for restoring NAD⁺ levels:
NAD⁺ Precursors:
- Nicotinamide Riboside (NR)
- Nicotinamide Mononucleotide (NMN)
- Nicotinic Acid (Niacin)
- These compounds enter NAD⁺ biosynthetic pathways, replenishing cellular stores.
Lifestyle Factors:
-
Exercise and caloric restriction can naturally increase NAD⁺ levels by improving mitochondrial function.
Direct NAD⁺ Supplementation & IV Therapy:
-
Research is ongoing regarding the bioavailability and efficacy of direct NAD⁺ administration.
Scientific & Clinical Relevance
Studies link optimal NAD⁺ levels to improvements in:
Metabolic health (glucose regulation, insulin sensitivity)
Neuroprotection (Alzheimer’s, Parkinson’s disease research)
Cardiovascular health
Longevity and healthy aging
Although murine testing results are promising, more clinical trials in humans are needed to confirm therapeutic potential.
Conclusion NAD+ peptide for sale
NAD⁺ is an indispensable molecule for life, governing energy production, DNA repair, gene regulation, and cell signaling. Its decline with age has made it a central focus in longevity research and metabolic health.
PLEASE NOTE THAT ALL PRODUCTS FEATURED HERE ARE INTENDED EXCLUSIVELY FOR RESEARCH AND DEVELOPMENT PURPOSES. THEY ARE NOT DESIGNED FOR ANY FORM OF HUMAN CONSUMPTION. THESE PRODUCTS HAVE NOT UNDERGONE EVALUATION BY THE U.S. FOOD AND DRUG ADMINISTRATION.
FOR ADDITIONAL INFORMATION AND LATEST SCIENTIFIC JOURNAL RESEARCH
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- “NAD+ Science 101 – What Is NAD+ & Why It’s Important,” Elysium Health. [Online]. Available: https://www.elysiumhealth.com/en-us/knowledge/science-101/everything-you-need-to-know-about-nicotinamide-adenine-dinucleotide-nad. [Accessed: 25-Jul-2019].
- “Nicotinamide Riboside: Benefits, Side Effects and Dosage,” Healthline. [Online]. Available: https://www.healthline.com/nutrition/nicotinamide-riboside. [Accessed: 25-Jul-2019].
- R. T. Matthews, L. Yang, S. Browne, M. Baik, and M. F. Beal, “Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects,” Proc. Natl. Acad. Sci. U. S. A., vol. 95, no. 15, pp. 8892–8897, Jul. 1998. [PMC]
- “What You Need to Know About Resveratrol Supplements,” WebMD. [Online]. Available: https://www.webmd.com/heart-disease/resveratrol-supplements. [Accessed: 25-Jul-2019].
- N. Sun, R. J. Youle, and T. Finkel, “The Mitochondrial Basis of Aging,” Mol. Cell, vol. 61, no. 5, pp. 654–666, Mar. 2016. [PMC]
- D. Stipp, “Beyond Resveratrol: The Anti-Aging NAD Fad,” Scientific American Blog Network. [Online]. Available: https://blogs.scientificamerican.com/guest-blog/beyond-resveratrol-the-anti-aging-nad-fad/. [Accessed: 08-Jul-2019].
- A. P. Gomes et al., “Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging,” Cell, vol. 155, no. 7, pp. 1624–1638, Dec. 2013. [PMC]
- S. Imai and L. Guarente, “NAD+ and sirtuins in aging and disease,” Trends Cell Biol., vol. 24, no. 8, pp. 464–471, Aug. 2014. [PubMed]
- A. R. Mendelsohn and J. W. Larrick, “Partial reversal of skeletal muscle aging by restoration of normal NAD+ levels,” Rejuvenation Res., vol. 17, no. 1, pp. 62–69, Feb. 2014. [PubMed]
- C. Kang, E. Chung, G. Diffee, and L. L. Ji, “Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: role of PGC-1α,” Exp. Gerontol., vol. 48, no. 11, pp. 1343–1350, Nov. 2013. [PubMed]
- S. Ringholm et al., “Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice; impact of PGC-1α,” Exp. Gerontol., vol. 48, no. 11, pp. 1311–1318, Nov. 2013. [PubMed]
- A. Lloret and M. F. Beal, “PGC-1α, Sirtuins and PARPs in Huntington’s Disease and Other Neurodegenerative Conditions: NAD+ to Rule Them All,” Neurochem. Res., May 2019. [PubMed]
- C. Shan et al., “Protective effects of β- nicotinamide adenine dinucleotide against motor deficits and dopaminergic neuronal damage in a mouse model of Parkinson’s disease,” Prog. Neuropsychopharmacol. Biol. Psychiatry, vol. 94, p. 109670, Jun. 2019. [PubMed]
- D. C. Maddison and F. Giorgini, “The kynurenine pathway and neurodegenerative disease,” Semin. Cell Dev. Biol., vol. 40, pp. 134–141, Apr. 2015. [PubMed]
- A. Garten, S. Schuster, M. Penke, T. Gorski, T. de Giorgis, and W. Kiess, “Physiological and pathophysiological roles of NAMPT and NAD metabolism,” Nat. Rev. Endocrinol., vol. 11, no. 9, pp. 535–546, Sep. 2015. [PubMed]
- S. Yamaguchi and J. Yoshino, “Adipose Tissue NAD+ Biology in Obesity and Insulin Resistance: From Mechanism to Therapy,” BioEssays News Rev. Mol. Cell. Dev. Biol., vol. 39, no. 5, May 2017. [PMC]
- J. E. Humiston, “Nicotinamide Adenine Dinucleotide,” p. 68. [FDA]
